Virus-Specific Antibody, Viral Load, and Disease Severity in Respiratory Syncytial Virus Infection
نویسندگان
چکیده
منابع مشابه
Viral Specific Factors Contribute to Clinical Respiratory Syncytial Virus Disease Severity Differences in Infants
BACKGROUND There is a wide range of severity of respiratory syncytial viral (RSV) disease in previously healthy infants. Host factors have been well demonstrated to contribute to disease severity differences. However the possibility of disease severity differences being produced by factors intrinsic to the virus itself has rarely been studied. METHODS Low-passage isolates of RSV collected pro...
متن کاملSeverity of Respiratory Syncytial Virus Lower Respiratory Tract Infection With Viral Coinfection in HIV-Uninfected Children.
Background Molecular diagnostics enable sensitive detection of respiratory viruses, but their clinical significance remains unclear in pediatric lower respiratory tract infection (LRTI). We aimed to determine whether viral coinfections increased life-threatening disease in a large cohort. Methods Molecular testing was performed for respiratory viruses in nasopharyngeal aspirates collected fro...
متن کاملSeverity of viral coinfection in hospitalized infants with respiratory syncytial virus infection.
OBJECTIVE To compare the severity of single respiratory syncytial virus (RSV) infections with that of coinfections. METHODS A historical cohort was studied, including hospitalized infants with acute RSV infection. Nasopharyngeal aspirate samples were collected from all patients to detect eight respiratory viruses using molecular biology techniques. The following outcomes were analyzed: durati...
متن کاملHuman Metapneumovirus and Severity of Respiratory Syncytial Virus Disease
We screened 23 children with severe respiratory syncytial virus (RSV) disease and 23 children with mild RSV disease for human metapneumovirus (HMPV). Although HMPV was circulating in Connecticut, none of the 46 RSV-infected patients tested positive for HMPV. In our study population, HMPV did not contribute to the severity of RSV disease.
متن کاملHuman genetic factors and respiratory syncytial virus disease severity.
SUMMARY To explain the wide spectrum of disease severity caused by respiratory syncytial virus (RSV) and because of the limitations of animal models to fully parallel human RSV disease, study of genetic influences on human RSV disease severity has begun. Candidate gene approaches have demonstrated associations of severe RSV in healthy infants with genetic polymorphisms that may alter the innate...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Infectious Diseases
سال: 2018
ISSN: 0022-1899,1537-6613
DOI: 10.1093/infdis/jiy106